As the British gained their edge over France, colonists began pressing for independence. The Revolutionary War confounded the Chickasaws, who saw it as "brothers fighting brothers" and tried to take a neutral position. The tribe's long allegiance to England came to an end as the Chickasaws shifted towards "Mountain Leader" Piominko's efforts to befriend the Americans.
Piominko's relationship with George Washington helped the tribe greatly, even as westward expansion began to erode Chickasaw borders. The transfer of Louisiana from France to Spain was a disturbing influence.