The threat of British invasion along the Gulf Coast prompted Chickasaw involvement

Although much of the fighting of the War of 1812 was far from Chickasaw lands, the threat of a British invasion on the Gulf Coast prompted the Chickasaw agent to request military aid from the tribe. Within a year, Chickasaws were said to be "in a high state of war" against the Creeks. General Andrew Jackson in Tennessee (as well as John Floyd in Georgia and Ferdinand Claiborne in the Mississippi Territory) formed militias in Louisiana. These militias mobilized for the Creek War and other battles and played a later role in the Battle of New Orleans.

The Battle of New Orleans, conducted on January 8, 1815, was the last major battle of the War of 1812. Andrew Jackson defeated the British army—some say in just 30 minutes—cementing his popularity with U.S. citizens and helping to catapult him into the presidency. War records indicate the following Chickasaw leaders joined U.S. forces in the War of 1812: George, William, James and Levi Colbert, Tishominko, William McGillivary, William Glover, James Brown, Samuel and Thomas Seeley and others.